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Recombinant Human Insulin, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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The Ireb2 D826V/D826V mutation results in increased body weight and lipid content in mice. (A) Human IREB2 mRNA expression is significantly reduced in obese individuals compared to lean individuals (n = 16 biological replicates for both lean and obese groups, *P < 0.05, relative to the lean group); (B) Mice with the Ireb2 D826V/D826V mutation exhibit greater body weight compared to WT mice; (C) 16 weeks Ireb2 D826V/D826V mutant mice demonstrate increased fat mass in epWAT and SAT relative to WT mice; (D) Triglyceride (TG) content is elevated in the epWAT and SAT of Ireb2 D826V/D826V mutant mice compared to WT mice; (E) Serum TG content is also increased in Ireb2 D826V/D826V mutant mice relative to WT mice; (F) Serum total cholesterol is increased in Ireb2 D826V/D826V mutant mice; (G) Food intake remains comparable between Ireb2 D826V/D826V mutant mice and WT mice; (H) Ireb2 D826V/D826V mutation slightly increased the fasting blood glucose level; (I) IPGTT detection and (J) ITT detection for WT and Ireb2 D826V/D826V mice; (K) Hypertrophic <t>adipocytes</t> are observed in the epWAT of Ireb2 D826V/D826V mutant mice compared to WT mice; (L) Similarly, hypertrophic adipocytes are present in the SAT of Ireb2 D826V/D826V mutant mice compared to WT mice (scale bar = 50 μm, B-J n = 5 biological replicates, *P < 0.05, **P < 0.01, ***P < 0.001, relative to the WT group using Student’s t-test).
Adipocytes, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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adipocytes - by Bioz Stars, 2026-03
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recombinant human insulin  (Valiant Co Ltd)
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The Ireb2 D826V/D826V mutation results in increased body weight and lipid content in mice. (A) Human IREB2 mRNA expression is significantly reduced in obese individuals compared to lean individuals (n = 16 biological replicates for both lean and obese groups, *P < 0.05, relative to the lean group); (B) Mice with the Ireb2 D826V/D826V mutation exhibit greater body weight compared to WT mice; (C) 16 weeks Ireb2 D826V/D826V mutant mice demonstrate increased fat mass in epWAT and SAT relative to WT mice; (D) Triglyceride (TG) content is elevated in the epWAT and SAT of Ireb2 D826V/D826V mutant mice compared to WT mice; (E) Serum TG content is also increased in Ireb2 D826V/D826V mutant mice relative to WT mice; (F) Serum total cholesterol is increased in Ireb2 D826V/D826V mutant mice; (G) Food intake remains comparable between Ireb2 D826V/D826V mutant mice and WT mice; (H) Ireb2 D826V/D826V mutation slightly increased the fasting blood glucose level; (I) IPGTT detection and (J) ITT detection for WT and Ireb2 D826V/D826V mice; (K) Hypertrophic <t>adipocytes</t> are observed in the epWAT of Ireb2 D826V/D826V mutant mice compared to WT mice; (L) Similarly, hypertrophic adipocytes are present in the SAT of Ireb2 D826V/D826V mutant mice compared to WT mice (scale bar = 50 μm, B-J n = 5 biological replicates, *P < 0.05, **P < 0.01, ***P < 0.001, relative to the WT group using Student’s t-test).
Recombinant Human Insulin, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/recombinant human insulin/product/Valiant Co Ltd
Average 95 stars, based on 1 article reviews
recombinant human insulin - by Bioz Stars, 2026-03
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The Ireb2 D826V/D826V mutation results in increased body weight and lipid content in mice. (A) Human IREB2 mRNA expression is significantly reduced in obese individuals compared to lean individuals (n = 16 biological replicates for both lean and obese groups, *P < 0.05, relative to the lean group); (B) Mice with the Ireb2 D826V/D826V mutation exhibit greater body weight compared to WT mice; (C) 16 weeks Ireb2 D826V/D826V mutant mice demonstrate increased fat mass in epWAT and SAT relative to WT mice; (D) Triglyceride (TG) content is elevated in the epWAT and SAT of Ireb2 D826V/D826V mutant mice compared to WT mice; (E) Serum TG content is also increased in Ireb2 D826V/D826V mutant mice relative to WT mice; (F) Serum total cholesterol is increased in Ireb2 D826V/D826V mutant mice; (G) Food intake remains comparable between Ireb2 D826V/D826V mutant mice and WT mice; (H) Ireb2 D826V/D826V mutation slightly increased the fasting blood glucose level; (I) IPGTT detection and (J) ITT detection for WT and Ireb2 D826V/D826V mice; (K) Hypertrophic <t>adipocytes</t> are observed in the epWAT of Ireb2 D826V/D826V mutant mice compared to WT mice; (L) Similarly, hypertrophic adipocytes are present in the SAT of Ireb2 D826V/D826V mutant mice compared to WT mice (scale bar = 50 μm, B-J n = 5 biological replicates, *P < 0.05, **P < 0.01, ***P < 0.001, relative to the WT group using Student’s t-test).
Insulin, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 96 stars, based on 1 article reviews
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The Ireb2 D826V/D826V mutation results in increased body weight and lipid content in mice. (A) Human IREB2 mRNA expression is significantly reduced in obese individuals compared to lean individuals (n = 16 biological replicates for both lean and obese groups, *P < 0.05, relative to the lean group); (B) Mice with the Ireb2 D826V/D826V mutation exhibit greater body weight compared to WT mice; (C) 16 weeks Ireb2 D826V/D826V mutant mice demonstrate increased fat mass in epWAT and SAT relative to WT mice; (D) Triglyceride (TG) content is elevated in the epWAT and SAT of Ireb2 D826V/D826V mutant mice compared to WT mice; (E) Serum TG content is also increased in Ireb2 D826V/D826V mutant mice relative to WT mice; (F) Serum total cholesterol is increased in Ireb2 D826V/D826V mutant mice; (G) Food intake remains comparable between Ireb2 D826V/D826V mutant mice and WT mice; (H) Ireb2 D826V/D826V mutation slightly increased the fasting blood glucose level; (I) IPGTT detection and (J) ITT detection for WT and Ireb2 D826V/D826V mice; (K) Hypertrophic <t>adipocytes</t> are observed in the epWAT of Ireb2 D826V/D826V mutant mice compared to WT mice; (L) Similarly, hypertrophic adipocytes are present in the SAT of Ireb2 D826V/D826V mutant mice compared to WT mice (scale bar = 50 μm, B-J n = 5 biological replicates, *P < 0.05, **P < 0.01, ***P < 0.001, relative to the WT group using Student’s t-test).
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The Ireb2 D826V/D826V mutation results in increased body weight and lipid content in mice. (A) Human IREB2 mRNA expression is significantly reduced in obese individuals compared to lean individuals (n = 16 biological replicates for both lean and obese groups, *P < 0.05, relative to the lean group); (B) Mice with the Ireb2 D826V/D826V mutation exhibit greater body weight compared to WT mice; (C) 16 weeks Ireb2 D826V/D826V mutant mice demonstrate increased fat mass in epWAT and SAT relative to WT mice; (D) Triglyceride (TG) content is elevated in the epWAT and SAT of Ireb2 D826V/D826V mutant mice compared to WT mice; (E) Serum TG content is also increased in Ireb2 D826V/D826V mutant mice relative to WT mice; (F) Serum total cholesterol is increased in Ireb2 D826V/D826V mutant mice; (G) Food intake remains comparable between Ireb2 D826V/D826V mutant mice and WT mice; (H) Ireb2 D826V/D826V mutation slightly increased the fasting blood glucose level; (I) IPGTT detection and (J) ITT detection for WT and Ireb2 D826V/D826V mice; (K) Hypertrophic <t>adipocytes</t> are observed in the epWAT of Ireb2 D826V/D826V mutant mice compared to WT mice; (L) Similarly, hypertrophic adipocytes are present in the SAT of Ireb2 D826V/D826V mutant mice compared to WT mice (scale bar = 50 μm, B-J n = 5 biological replicates, *P < 0.05, **P < 0.01, ***P < 0.001, relative to the WT group using Student’s t-test).
Bt Lab Detection Kit, supplied by Shanghai Korain Biotech Co Ltd, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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The Ireb2 D826V/D826V mutation results in increased body weight and lipid content in mice. (A) Human IREB2 mRNA expression is significantly reduced in obese individuals compared to lean individuals (n = 16 biological replicates for both lean and obese groups, *P < 0.05, relative to the lean group); (B) Mice with the Ireb2 D826V/D826V mutation exhibit greater body weight compared to WT mice; (C) 16 weeks Ireb2 D826V/D826V mutant mice demonstrate increased fat mass in epWAT and SAT relative to WT mice; (D) Triglyceride (TG) content is elevated in the epWAT and SAT of Ireb2 D826V/D826V mutant mice compared to WT mice; (E) Serum TG content is also increased in Ireb2 D826V/D826V mutant mice relative to WT mice; (F) Serum total cholesterol is increased in Ireb2 D826V/D826V mutant mice; (G) Food intake remains comparable between Ireb2 D826V/D826V mutant mice and WT mice; (H) Ireb2 D826V/D826V mutation slightly increased the fasting blood glucose level; (I) IPGTT detection and (J) ITT detection for WT and Ireb2 D826V/D826V mice; (K) Hypertrophic adipocytes are observed in the epWAT of Ireb2 D826V/D826V mutant mice compared to WT mice; (L) Similarly, hypertrophic adipocytes are present in the SAT of Ireb2 D826V/D826V mutant mice compared to WT mice (scale bar = 50 μm, B-J n = 5 biological replicates, *P < 0.05, **P < 0.01, ***P < 0.001, relative to the WT group using Student’s t-test).

Journal: Frontiers in Cell and Developmental Biology

Article Title: The D826V point mutation in IREB2 induces lipogenesis in adipose tissues

doi: 10.3389/fcell.2026.1724485

Figure Lengend Snippet: The Ireb2 D826V/D826V mutation results in increased body weight and lipid content in mice. (A) Human IREB2 mRNA expression is significantly reduced in obese individuals compared to lean individuals (n = 16 biological replicates for both lean and obese groups, *P < 0.05, relative to the lean group); (B) Mice with the Ireb2 D826V/D826V mutation exhibit greater body weight compared to WT mice; (C) 16 weeks Ireb2 D826V/D826V mutant mice demonstrate increased fat mass in epWAT and SAT relative to WT mice; (D) Triglyceride (TG) content is elevated in the epWAT and SAT of Ireb2 D826V/D826V mutant mice compared to WT mice; (E) Serum TG content is also increased in Ireb2 D826V/D826V mutant mice relative to WT mice; (F) Serum total cholesterol is increased in Ireb2 D826V/D826V mutant mice; (G) Food intake remains comparable between Ireb2 D826V/D826V mutant mice and WT mice; (H) Ireb2 D826V/D826V mutation slightly increased the fasting blood glucose level; (I) IPGTT detection and (J) ITT detection for WT and Ireb2 D826V/D826V mice; (K) Hypertrophic adipocytes are observed in the epWAT of Ireb2 D826V/D826V mutant mice compared to WT mice; (L) Similarly, hypertrophic adipocytes are present in the SAT of Ireb2 D826V/D826V mutant mice compared to WT mice (scale bar = 50 μm, B-J n = 5 biological replicates, *P < 0.05, **P < 0.01, ***P < 0.001, relative to the WT group using Student’s t-test).

Article Snippet: Differentiation of Ireb2 D826V/D826V and WT pre-adipocytes into adipocytes was induced using media containing insulin (HY- P73243 , 10 mg/mL, Medchemexpress, China), dexamethasone (HY-14648,10 μM, Medchemexpress, China), 3-isobutyl-1-methylxanthine (HY-12318, IBMX, 0.5 M, Medchemexpress, China), indomethacin (HY-14397, 125 nM, Medchemexpress, China), and rosiglitazone (HY-17386, 1 μM, Medchemexpress, China) for 5 days, followed by treatment with insulin (10 mg/mL) for an additional 2 days.

Techniques: Mutagenesis, Expressing

In vitro experiments demonstrated that the Ireb2 D826V/D826V mutation enhances lipid biosynthesis in mature adipocytes. (A) Oil Red O staining was performed on WT and Ireb2 D826V/D826V mature adipocytes; (B) The Ireb2 D826V/D826V mutation led to an increase in TG content in mature adipocytes; (C) The mutation also elevated fatty acid content in mature adipocytes; (D) Western blot analysis was conducted to assess the expression of proteins related to fatty acid and triglyceride biosynthesis, as well as IREB2 and FTH1, in mature adipocytes; (E) Relative band intensity analysis was carried out for IREB2 and FTH1 proteins; (F) Relative band intensity analysis was conducted for EGR1 and FGFR4 proteins; (G) Relative band intensity analysis was performed for FASN, ACACA, and ACLY proteins; (H) Lipogenic related mRNA expression in Ireb2 D826V/D826V adipocytes and Ireb2 D826V/D826V + deferoxamine adipocytes; (I) TG content in Ireb2 D826V/D826V adipocytes and Ireb2 D826V/D826V + deferoxamine adipocytes; (J) FA content in Ireb2 D826V/D826V adipocytes and Ireb2 D826V/D826V + deferoxamine adipocytes. (A-C n = 5 biological replicates; D-G n = 3 biological replicates, H-J n = 4 biological replicates, *P < 0.05, **P < 0.01, ***P < 0.001, (A-G) compared with the WT group using Student’s t-test; (H-J) compared with the Ireb2 D826V/D826V group using Student’s t-test.

Journal: Frontiers in Cell and Developmental Biology

Article Title: The D826V point mutation in IREB2 induces lipogenesis in adipose tissues

doi: 10.3389/fcell.2026.1724485

Figure Lengend Snippet: In vitro experiments demonstrated that the Ireb2 D826V/D826V mutation enhances lipid biosynthesis in mature adipocytes. (A) Oil Red O staining was performed on WT and Ireb2 D826V/D826V mature adipocytes; (B) The Ireb2 D826V/D826V mutation led to an increase in TG content in mature adipocytes; (C) The mutation also elevated fatty acid content in mature adipocytes; (D) Western blot analysis was conducted to assess the expression of proteins related to fatty acid and triglyceride biosynthesis, as well as IREB2 and FTH1, in mature adipocytes; (E) Relative band intensity analysis was carried out for IREB2 and FTH1 proteins; (F) Relative band intensity analysis was conducted for EGR1 and FGFR4 proteins; (G) Relative band intensity analysis was performed for FASN, ACACA, and ACLY proteins; (H) Lipogenic related mRNA expression in Ireb2 D826V/D826V adipocytes and Ireb2 D826V/D826V + deferoxamine adipocytes; (I) TG content in Ireb2 D826V/D826V adipocytes and Ireb2 D826V/D826V + deferoxamine adipocytes; (J) FA content in Ireb2 D826V/D826V adipocytes and Ireb2 D826V/D826V + deferoxamine adipocytes. (A-C n = 5 biological replicates; D-G n = 3 biological replicates, H-J n = 4 biological replicates, *P < 0.05, **P < 0.01, ***P < 0.001, (A-G) compared with the WT group using Student’s t-test; (H-J) compared with the Ireb2 D826V/D826V group using Student’s t-test.

Article Snippet: Differentiation of Ireb2 D826V/D826V and WT pre-adipocytes into adipocytes was induced using media containing insulin (HY- P73243 , 10 mg/mL, Medchemexpress, China), dexamethasone (HY-14648,10 μM, Medchemexpress, China), 3-isobutyl-1-methylxanthine (HY-12318, IBMX, 0.5 M, Medchemexpress, China), indomethacin (HY-14397, 125 nM, Medchemexpress, China), and rosiglitazone (HY-17386, 1 μM, Medchemexpress, China) for 5 days, followed by treatment with insulin (10 mg/mL) for an additional 2 days.

Techniques: In Vitro, Mutagenesis, Staining, Western Blot, Expressing